Christine E. Gee


Institute for Synaptic Physiology (ISP)
Center for Molecular Neurobiology Hamburg (ZMNH)
Falkenried 94
20251 Hamburg
Phone: +49 40 7410 57 638
Fax: +49 40 7410 58 364
ORCID-ID: 0000-0003-0345-3665

Collaborators, past & present:


  1. Lamothe-Molina PJ, Franzelin A, Beck L, Li D, Auksutat L, Fieblinger T, Laprell L, Alhbeck J, Gee CE, Kneussel M, Engel AK, Hilgetag CC, Morellini F, Oertner TG (2022) ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning.
    Nat Commun 13(1):6376.
  2. Fieblinger T, Perez-Alvarez A, Lamothe-Molina PJ, Gee CE, Oertner TG (2022) Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning.
    EMBO Rep 23(8):e54361.
  3. Chen F, Duan X, Yu Y, Yang S, Chen Y, Gee CE, Nagel G, Zhang K, Gao S, Shen Y (2022) Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice.
    Signal Transduct Target Ther. 7(1):104.
  4. Fearey BC, Binkle L, Mensching D, Schulze C, Lohr C, Friese MA, Oertner TG, Gee CE (2022) A glibenclamide-sensitive TRPM4-mediated component of CA1 excitatory postsynaptic potentials appears in experimental autoimmune encephalomyelitis
    Sci Rep 12(1):6000.
  5. Anisimova M, van Bommel B, Wang R, Mikhaylova M, Wiegert JS, Oertner TG*, Gee CE* (2022) Spike-timing-dependent plasticity rewards synchrony rather than causality.
    Cereb Cortex 33(1):23-34. *Co-last authors
  6. Woelk LM, Kannabiran SA, Brock VJ, Gee CE, Lohr C, Guse AH, Diercks BP, Werner R (2021) Time-Dependent Image Restoration of Low-SNR Live-Cell Ca2 Fluorescence Microscopy Data.
    Int J Mol Sci 22(21):11792.
  7. Lohr C, Beiersdorfer A, Fischer T, Hirnet D, Rotermund N, Sauer J, Schulz K, Gee CE (2021) Using Genetically Encoded Calcium Indicators to Study Astrocyte Physiology: A Field Guide
    Front Cell Neurosci 15:690147.
  8. Yang S*, Constantin OM*, Sachidanandan D*, Hofmann H, Kunz TC, Kozjak-Pavlovic V, Oertner TG, Nagel G, Kittel RJ*, Gee CE*, Gao S* (2021) PACmn for improved optogenetic control of intracellular cAMP
    BMC Biology 19: 227. * equal contribution / co-corresponding
  9. Gee CE, Oertner TG (2021) Photoactivatable CaMKII: Rewiring the Brain, One Synapse at a Time
    Trends in Neurosciences 44(4): 4.
  10. Mitlöhner J, Kaushik R, Niekisch H, Blondiaux A, Gee CE, Happel MFK, Gundelfinger E, Dityatev A, Frischknecht R, Seidenbecher C (2020) Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses
    Cells 9(2):260.
  11. Perez-Alvarez A*, Fearey B*, Schulze C, O'Toole RJ, Moeyaert B, Mohr MA, Arganda-Carreras I, Yang W, Wiegert JS, Schreiter ER, Gee CE, Hoppa MB, Oertner TG (2019) Freeze-frame imaging of synaptic activity using SynTagMA
    Nature Communications 11: 2464.
  12. Beck S, Yu-Strzelczyk J, Pauls D, Constantin OM, Gee CE, Ehmann N, Kittel RJ, Nagel G, Gao S (2018) Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition.
    Front. Neurosci. 12:643.
  13. Moeyaert B, Holt G, Madangopal R, Perez-Alvarez A, Fearey BC, Trojanowski NF, Ledderose J, Zolnik TA, Das A, Patel D, Brown TA, Sachdev RNS, Eickholt BJ, Larkum ME, Turrigiano GG, Dana H, Gee CE, Oertner TG, Hope BT, Schreiter ER (2018) Improved methods for marking active neuron populations.
    Nat Commun. 9(1):4440.
  14. Gromova KV, Muhia M, Rothammer N, Gee CE, Thies E, Schaefer I, Kress S, Kilimann MW, Shevchuk O, Oertner TG, Kneussel M (2018) Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.
    Cell Rep. 23(9):2705-2717.
  15. Scheib U, Broser M, Constantin OM, Yang S, Gao S, Mukherjee S, Stehfest K, Nagel G, Gee CE*, Hegemann P* (2018) Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain.
    Nat Commun. 9(1):2046. *co-last authors
  16. S. H. Bitzenhofer, J. Ahlbeck, A. Wolff, J. S. Wiegert, C. E. Gee, T. G. Oertner, I. L. Hanganu-Opatz (2017) Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks.
    Nat Commun. 8:14563.
  17. Wiegert JS, Gee CE, Oertner TG (2017) Stimulating Neurons with Heterologously Expressed Light-Gated Ion Channels.
    Cold Spring Harb Protoc. doi:10.1101/pdb.top089714
  18. Gee CE, Ohmert I, Wiegert JS, Oertner TG (2017) Preparation of Slice Cultures from Rodent Hippocampus.
    Cold Spring Harb Protoc. doi:10.1101/pdb.prot094888
  19. Wiegert JS, Gee CE, Oertner TG (2017) Viral Vector-Based Transduction of Slice Cultures .
    Cold Spring Harb Protoc. doi:10.1101/pdb.prot094896
  20. Wiegert JS, Gee CE, Oertner TG (2017) Single-Cell Electroporation of Neurons.
    Cold Spring Harb Protoc. doi:10.1101/pdb.prot094904
  21. Gee CE, Oertner TG (2016) Pull out the stops for plasticity. (News and Views)
    Nature 529, 164-165.
  22. Scheib U, Stehfest K, Gee CE, Körschen HG, Fudim R, Oertner TG, Hegemann P (2015) The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling.
    Science Signaling 8, rs8.
  23. Behnke D, Cotesta S, Hintermann S, Fendt M, Gee CE, Jacobson LH, Laue G, Meyer A, Wagner T, Badiger S, Chaudhari V, Chebrolu M, Pandit C, Hoyer D, Betschart C (2015) Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).
    Bioorg Med Chem Lett. 25(23):5555-60.
  24. Gee CE, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, Uschold-Schmidt N, Feuerbach D, Zimmermann K, Ofner S, Cryan JF, van der Putten H, Fendt M, Vranesic I, Glatthar R, Flor PJ (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
    J Biol Chem. 289(16): 10975-87.
  25. Callander GE, Olorunda M, Monna D, Schuepbach E, Langenegger D, Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Laue G, Ofner S, Briard E, Gee CE, Jacobson LH, Hoyer D (2013) Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.
    Frontiers in Neuroscience 7:320.
  26. Hoyer D, Dürst T, Fendt M, Jacobson LH, Betschart C, Hintermann S, Behnke D, Cotesta S, Laue G, Ofner S, Legangneux E, Gee CE (2013) Distinct effects of IPSU and suvorexant on mouse sleep architecture.
    Frontiers in Neuroscience 7:235.
  27. Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Gee CE, Jacobson LH, Laue G, Ofner S, Chaudhari V, Badiger S, Pandit C, Wagner J, Hoyer D (2013) Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia.
    J Med Chem. 56(19):7590-7607.
  28. Fendt M, Imobersteg S, Peterlik D, Chaperon F, Mattes C, Wittmann C, Olpe HR, Mosbacher J, Vranesic I, van der Putten H, McAllister KH, Flor PJ, Gee CE (2013) Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology.
    Neuropharmacology 72:215-23.
  29. Mang GM, Duerst T, Buerki H, Imobersteg S, Abramowski D, Schuepbach E, Hoyer D, Fendt M, Gee CE (2012) The dual orexin receptor antagonist almorexant induces sleep and decreases orexininduced locomotion by blocking orexin 2 receptors.
    Sleep 35(12): 1625-35.
  30. Chaperon F, Fendt M, Kelly PH, Lingenhoehl K, Mosbacher J, Olpe HR, Schmid P, Sturchler C, McAllister KH, van der Putten PH, Gee CE (2012) Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory.
    PLoS ONE 7(4): e34963.
  31. Gee CE, Benquet P, Demont-Guignard S, Wendling F, Gerber U (2010)
    Energy deprivation transiently enhances rhythmic inhibitory events in the CA3 hippocampal network in vitro.
    Neuroscience 168(3): 605-12.
  32. Matsumoto-Miyai K, Sokolowska E, Zurlinden A, Gee CE, Lüscher D, Hettwer S, Wölfel J, Ladner A P, Ster J, Gerber U, Rülicke, T, Kunz B, Sonderegger P (2009)
    Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage.
    Cell 136: 1161-71.
  33. Benquet P, Gee CE, Gerber U (2008)
    Transient brain ischemia: NMDA receptor modulation and delayed neuronal death.
    Medecine Sciences (Paris) 24(2):185-90.
  34. Hédou GF, Koshibu K, Farinelli M, Kilic E, Gee CE, Kilic U, Baumgärtel K, Hermann DM, Mansuy IM (2008)
    Protein phosphatase 1-dependent bidirectional synaptic plasticity controls ischemic recovery in the adult brain.
    Journal of Neuroscience 28(1):154-62.
  35. Gerber U, Gee CE, Benquet P (2007)
    Metabotropic glutamate receptors: intracellular signaling pathways.
    Current Opinion in Pharmacology 7(1):56-61.
  36. Gee CE, Benquet P, Raineteau O, Rietschin L, Kirbach SW, Gerber U (2006)
    NMDA receptors and the differential ischemic vulnerability of hippocampal neurons.
    European Journal of Neuroscience 23(10):2595-603.
  37. Gee CE,  Mansuy I (2005)
     Protein phosphatases and their potential implications in neuroprotective processes.
    Cell Mol. Life Sci. 62:1120-1130.
  38. Grishin AA, Gee CE, Gerber U, Benquet P (2004)
    Differential calcium-dependent modulation of NMDA currents in CA1 and CA3 hippocampal pyramidal cells.
    Journal of Neuroscience 24(2):350-5.
  39. Gee CE, Woodhall GL, Lacaille JC (2001)
    Synaptically activated calcium responses in dendrites of hippocampal oriens-alveus interneurons.
    Journal of Neurophysiology 85:1603-1613.
  40. Woodhall G, Gee CE, Robitaille R, Lacaille JC (1999)
    Membrane potential and intracellular Ca2+ oscillations activated by mGluRs in hippocampal stratum oriens/alveus interneurons.
    Journal of Neurophysiology 81:371-382.
  41. Gee CE, Shoemaker KL, Robertson RM (1998)
    The forewing tegulae: Significance for steering manoeuvres and free flight in Locusta migratoria.
    Can. J. Zool. 76:660-667.
  42. Gee CE, Robertson RM (1998)
    Free-flight ability in locusts recovering from propriceptive injury.
    Naturwissenschaften 85:167-170.
  43. Gee CE, Robertson RM (1994)
    Effects of maturation on synaptic potentials in the locust flight system.
    J. Comp. Physiol. [A]175: 437-447.
  44. Kent KS, Pearce J, Gee C, Govind CK (1989)
    Regenerative fidelity in the paired claw closer muscles of lobsters.
    Can. J. Zool.
    67: 1573-1577.

Page last updated January 4, 2023 by Christine Gee